One of my favourite aesthetic techniques is using the Pillar Middle foundation piece for running conveyor belts and pipes.
If you use trains to transport resources then you are going to want to make sure the train can supply enough resources to last the round trip. This video explains how to calculate this along with a working example. This video also explains the theory behind using buffers for the freight platforms.
A Smart or Programmable Splitter allows you to define which output of a splitter a product can be directed. Using the overflow feature of the splitter allows for excess product to be directed somewhere like the AWESOME Sink which in turn prevents your production lines from going dormant.
Unlocking the Oil Processing milestone gives access to the Oil Extractor and the Refinery. I'll explain how Refineries work and how they have dual inputs and outputs and how you need to manage them.
This guide shows you how build a temporary setup to generate plastic and rubber.
Here I will demonstrate how to build vertically for a copper node making copper products.
Manual Automation shows you how to use storage containers for the inputs and outputs of a machine and hence you can fill those containers with materials and parts will automatically be created, all you need to do is top up the containers occasionally.
There's lots of debate between which is the better choice, Manifold or Load Balance. This article demonstrates both techniques.
Parts Per Minute is a key concept of the game, the buildings in the game input and output resources at a rate per minute. This also relates directly to the different conveyor belts that have different speeds.